博士，现任上海交通大学医学院细胞分化与凋亡教育部重点实验室研究员、课题组长。2002年毕业于北京大学药理系，获理学学位，北京大学优秀毕业生。2007年于中国科学院上海药物研究所获得博士学位，上海市优秀博士毕业生。2007年至2009年在University of Michigan肿瘤中心做博士后研究，从事针对Dopamine3和MDM2靶标的药物开发。曾获Roche Chemistry Creative Award，中国科学院“院长特别奖”和全国百篇优秀博士论文。作为主要成员及主要学术骨干参加过自然科学基金、863及973项目研究。
      主要从事计算生物学、药物设计及化学生物学领域，致力于计算生物学、计算化学和生物信息学新算法发展, 重要疾病靶标作用机制及通路研究和相关药物的开发，取得了系统和创新的成果。他发展了一系列药物设计和计算生物学方法，包括：基于靶标结构的药物设计、组合集中库设计、从头药物设计等多种新方法；活性小分子和结合蛋白质相互作用的新评价系统；蛋白质相互作用有效亚结构提取、基因组水平预测蛋白质－蛋白质相互作用（PPI）网络和潜在蛋白质结合对象的理论方法等，这些方法受到了国际同行关注；与他人合作应用药物设计方法，结合化学合成和药理筛选，针对10余个重要药物靶标进行了系统性的药物设计研究，发现活性化合物100余个，其中针对Dopamine3的化合物即将进入临床前研究，针对MDM2的化合物已经进入临床I期研究；与他人合作利用活性小分子为探针，结合计算生物学和结构生物学，发现新型药物作用靶标和相关药理作用；在超级计算机上对10余种重要受体蛋白质的药理功能进行了分子动力学模拟研究，特别是在蛋白质大规模构象变化与生物功能的关系研究方面，做出了高水平的工作。
      他以第一作者身份在PNAS、JACS、JBC、JCC、Bioorg. Med. Chem. Lett、Bioorg. Med. Chem.等国际刊物上发表研究论文10余篇；参加翻译J. Licinio和M.-L. Wong主编的《药物基因组学》；申请专利4项；多次在国内和国际学术会议作邀请报告。

1. Jian Zhang, Chenjing Li, Ting Shi, Kaixian Chen, Xu Shen, Hualiang Jiang. Lys169 of Human Glucokinase Is a Determinant for Glucose Phosphorylation: Implication for the Atomic Mechanism of Glucokinase Catalysis.  PLOS ONE, 2009 Jul 20; 4(7): e6304.
2. Jian Zhang, Chenjing Li, Kaixian Chen, Weiliang Zhu, Xu Shen, Hualiang Jiang. Conformational transition pathway in the allosteric process of human glucokinase, Proc. Natl. Acad. Sci. USA. 2006，103(36),13368-13373.
3. Juwen Shen1, Jian Zhang1 (1为共同第一作者), Xiaomin Luo, Weiliang Zhu, Kunqian Yu, Yixue Li, Hualiang Jiang. Predicting protein-protein interactions based only on sequences information.  Proc. Natl. Acad. Sci. USA., 2007,104(11),4337-4341.
4. Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Jian Zhang, Lu Y, Gu Q, Shah RB, Pienta KJ, Ling X, Kang S, Guo M, Sun Y, Yang D, Wang S. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition，Proc. Natl. Acad. Sci. USA., 2008, 105(10), 3933-3938.
5. Jian Zhang, Yechun Xu, Jianhua Shen, Xiaomin Luo, Jiagao Chen, Kaixian Chen, Weiliang Zhu, and Hualiang Jiang. Dynamic Mechanism for the Autophosphorylation of CheA Histidine Kinase: Molecular Dynamics Simulations, J. AM. CHEM. SOC., 2005, 127(33), 11709-11719.
6. Shuai Chen1, Tiancen Hu1, Jian Zhang1(1为共同第一作者), Jing Chen, Kaixian Chen, Hualiang Jiang, and Xu Shen. Mutation of Gly11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of SARS-CoV 3CLpro: Crystal Structure in Conjunction with Molecular Dynamics Simulations, J.Biol.Chem 2008，283(1), 554-564.
7. Cong Han1, Jian Zhang1(1为共同第一作者), Lili Chen, Kaixian Chen, Xu Shen, Hualiang Jiang. Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling.  Bioorg. Med. Chem. ,2007, 15(2), 656-662.
8. Jian Zhang, KunQian Yu, Weiliang Zhu, Hualiang Jiang. Neuraminidase pharmacophore model derived from diverse classes of inhibitors, Bioorg. Med. Chem. Lett., 2006, 16(11), 3009-3014.
9. Jian Li1, Jian Zhang1(1为共同第一作者), Jing Chen, Xiaomin Luo, Weiliang Zhu, Jianhua Shen, Hong Liu, Xu Shen, Hualiang, Jiang. An Effective Strategy for Discovering Novel Chemical Inhibitors of Human Cyclophilin A: Focused Library Design, Virtual Screening, Chemical Synthesis and Bioassay, J. Comb. Chem., 2006, 8(3), 326-337.
10. Zhiqiang Qin1, Jian Zhang1(1为共同第一作者), Bin Xu, Lili Chen, Yang Wu, Yuanzhu Ou, Xiaomei Yang, Xu Shen, Hualiang Jiang, Di Qu. Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections，BMC MICROBIOL., 2006, 6, 96-114.
11. Sanjeev K, Zaneta N.C., Donna M., Rebecca M., Jianyong Chen, Meilan Liu, Su Qiu, Jian Zhang, Shaomeng, Wang. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition，Proc. Natl. Acad. Sci. USA., in press.
12. Aijun Lu, Jian Zhang, Xiaojin Yin, Xiaomin Luo, Hualiang Jiang. Farnesyltransferase pharmacophore model derived from diverse classes of inhibitors. Bioorg. Med. Chem. Lett. 2007, 15, 243-249.
13. Shuai Chen, Jian Zhang, Lili Chen, Kaixian Chen, Hualiang Jiang, and Xu Shen. Residues on the Dimer Interface of SARS Coronavirus 3C-like Protease: Dimer Stability Characterization and Enzyme Catalytic Activity Analysis, The Journal of Biochemistry in press.
14. Deju Ye, Jian Li, Jian Zhang, Hong Liu, Hualiang Jiang. Simultaneous stereoselective 4-amination with cyclic secondary amines and 2-O-deacetylation of peracetylated sialic acid derivatives Tetrahedron Letter 2007, in press.
15. Min Huang, Heyong Gao, Yi Chen, Hong Zhu, Yujun Cai， Xiongwen Zhang, Zehong Miao, Hualiang Jiang, Jian Zhang, Hongwu Shen, Liping Lin, Wei Lu and Jian Ding. Chimmitecan, a Novel 9-Substituted Camptothecin, with Excellent Improvement in Anti-cancer Pharmacological Profiles both In Vitro and In Vivo. Clincial Cancer Research, 2007, 6(2), 484-495.
16. Zhiqiang Qin, Baoleri Lee, Lei Yang, Jian Zhang, Xiaomei Yang, Di Qu, Hualiang Jiang, Soeren Molin. Anti-microbial Activities of YycG Histidine Kinase Inhibitors against Staphylococcus epidermidis Biofilms. FEMS Microbiology Letters, 2007, 273(2), 149-156..
17. Jianhua Cai, Cong Han, Tianchen Hu, Jian Zhang, Fangdao Wang, Yunqing Liu, Jianping Ding, Kaixian Chen, Jianmin Yue, Xu Shen, Hualiang Jiang. PDF Enzyme is a Potential Target for Anti-Helicobacter pylori Drugs: Reverse Docking, Enzymatic assay and X-ray Crystallography Validation, Protein Sci., 2006, 15(9), 2071-2081.
18. Jian Li, Jing Chen, Chunshan Gui, Li Zhang, Yu Qin, Qiang Xu, Jian Zhang, Hong Liu, Xu Shen and Hualiang Jiang. Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay, Bioorgan. Med. Chem., 2006,14(7), 2209-2224.
19. Jian Li, Jin-zhi Tan, Li-li Chen, Jian Zhang, Xu Shen, Chang-lin Mei, Li-li Fu, Li-ping Lin, Jian Ding, Bing Xiong, Hong Liu, Xiao-min Luo, Hua-liang Jiang. Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives. Acta Pharmacologica Sinica 2006, 27(9), 1259-1271.
20. Gang Chen, Suxin Zheng, Xiaomin Luo, Jianhua Shen, Weiliang Zhu, Hong Liu, Chunshan Gui, Jian Zhang, Mingyue Zheng, Chum Mok Puah, Kaixian Chen, and Hualiang Jiang. Focused Combinatorial Library Design Based on Structural Diversity, Druglikeness and Binding Affinity Score, J. Comb. Chem., 2005, 7(3), 398-406.
21. Xiaoyan Qiu, Xiaohui Zhu, Liang Zhang, Yuntao Mao, Jian Zhang, Peng Hao, Guohui Li, Peng Lv, Zhixin Li, Xin Sun, Lemeng Wu, Jie Zheng, Yuqing Deng, Chunmei Hou, Peixian Tang, Shuren Zhang and Youhui Zhang. Human Epithelial Cancers Secrete Immunoglobulin G with Unidentified Specificity to Promote Growth and Survival of Tumor Cells. Cancer Research, 2003(63): 6488-6495.
22. Jian Zhang, Xiao-Hui Zhu, Peng Hao, Yun-Tao Mao, Xin Sun, Le-Meng Wu, Guo-Hui Li, Xiao-Yan Qiu. Immunoglobulin G expression in lung cancer cells. ACTA BIOCHIMICA et BIOPHYSICA SINICA 2003, 35(2): 197-214.