课题组长
赵倩
研究方向:肿瘤细胞分化与凋亡
办公地址:重庆南路280号新教学楼905室
办公电话:86-021-63846590*776920
邮箱地址:qzhao@shsmu.edu.cn
个人简介
赵倩，女，博士，副研究员，上海交通大学医学院病理生理学教研室主任 。
赵倩博士分别于上海交通大学生物科学与技术系和复旦大学生物化学系获得学士和硕士学位。其后进入中科院细胞生物学研究所，从事细胞凋亡机制研究。1999-2002年间，在上海第二医科大学血液学研究所攻读博士学位，主要致力于白血病细胞分化机制研究。2002年取得博士学位后，协助陈国强教授组建中科院上海生命科学研究院-上海第二医科大学健康科学中心肿瘤功能基因组学研究室，继续从事白血病诱导分化机制以及肿瘤基因组学研究。2006年9月至2007年9月，在美国University of Rochester医学中心进行合作研究。2004年入选上海市“青年科技启明星”计划。
近年来承担了一系列国家级科研课题。作为课题负责人，获得国家自然科学基金2项，获得国家863专题课题1项，作为子课题负责人，获得国家973课题1项。
2005年作为第二完成人分别获得中华医学科技奖一等奖，上海市科学技术进步奖一等奖和上海医学科技奖一等奖。
部分已发表文章
1. Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q, Chen GQ, Li D. NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells. Leuk Res. 2009;33 (8):1108-13
2. Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ. Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica. 2008 Oct;93(10):1480-7
3. Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ. Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene. 2008 Jan 17;27(4):519-27.
4. Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene. 2006 Oct 26;25(50):6618-27.
5. Huang Y, Zhao Q, Chen GQ. Phospholipid scramblase 1. Acta Physiologica Sinica. 2006 Dec 25;58(6):501-510. PMID: 17173184 (Review)
6. Chen GQ, Peng ZG, Liu W, Song LP, Jiang Y, Huang Y, Zhao Q. Hypoxia inducible factor-1alpha and leukemic cell differentiation. Acta Physiologica Sinica. 2006 Feb 25; 58(1): 5-13.
7. Ren HY，Cao Y，Zhao QJ, Li J, Zhou CX, Liao LM, Jia MY, Zhao Q, Cai HG, Han ZC, Yang RC, Chen GQ, Zhao R.C. Proliferation and diferentiation of bone marrow stromal cells under hypoxic conditions. Biochem Biophys Res Commun. 2006; 347: 12-21.
8. Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ. Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. J Biol Chem. 2005 Dec 30; 280(52): 42707-14.
9. Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica. 2005 Dec; 90(12): 1607-16.
10. Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ，Zhao Q. Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1α protein. Biochem Biophys Res Commun. 2005; 332(4), 1140-5.
11. Zhao KW, Li X, Zhao Q, Huang Y, Peng ZG, Shen WZ, Zhao J, Zhou QS, Chen Z, Sims PJ, Wiedmer T, Chen GQ. Protein Kinase Cdelta Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation. BLOOD. 2004 Dec 1; 104(12): 3731-8.
12. Zhao Q, Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation. Leukemia. 2004; 18 (2): 285-92.
13. Huang Y, Du KM, Xue ZH, Yan H, Li D, Liu W, Chen Z, Zhao Q, Tong JH, Zhu YS, Chen GQ. Cobalt Chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-alpha. Leukemia.2003; 17(11): 2065-73.
14. Cai X, Yu Y, Huang Y, Zhang L, Jia PM, Zhao Q, Chen Z, Tong JH, Dai W, Chen GQ. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. Leukemia.2003; 17 (7): 1333-7.
15. Zhang XJ, Yang L, Zhao Q, Caen JP, He HY, Jin QH, Guo LH, Alemany M, Zhang LY, Shi YF. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell Death Differ. 2002; 9(8): 790-800.