详细信息
学术骨干
赵克温
办公地址:重庆南路280号新教学楼907室
办公电话:86-021-63846590*776403
邮箱地址:zkewen@sjtu.edu.cn
个人简介

赵克温,女,博士,副研究员。

2002年在山东大学生命科学研究院获得发育生物学硕士。2005年在中国科学院上海生命科学研究院-上海交通大学医学院健康科学研究所获得生物化学与分子生物学博士学位。2005年博士毕业后,加入上海交通大学医学院病理生理学教研室、“细胞分化与凋亡教育部重点实验室”工作。期间主要从事磷脂酰爬行酶在白血病细胞分化中的功能及其表达调控的信号转导通路研究。2006-2008年3月被教研室派往美国Emory大学Winship癌症研究所进行博士后培训,主要从事转录因子KLF5相互作用蛋白网络的识别鉴定及其在上皮细胞性癌症(包括前列腺癌及乳腺癌)中的功能研究。伴随着上海交通大学医学院病理生理教研室、“细胞分化与凋亡教育部重点实验室”这个优秀的集体一起成长,2005年获得中华医学奖一等奖(第三完成人),上海市医学科技奖一等奖(第三完成人),上海市科技进步一等奖(第三完成人)。2007年获得上海市医学科技奖一等奖(第五完成人)。作为课题负责人获得国家自然科学基金项目一项。2006年,入选上海市青年科技启明星计划。

部分已发表文章
1.    Zhao BX, Du AY, Miao JY, Zhao KW, Du CQ. Effects of novel safrole oxide derivatives, 1-methoxy-3-(3,4-methylenedioxyphenyl)-2-propanol and 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, on apoptosis induced by deprivation of survival factors in vascular endothelial cells. Vascul Pharmacol. 2003; 40(3):183-7.
2.    Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ. Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation. Blood. 2004; 104(12): 3731-8.
3.    Zhao KW, Zhao QT, Zhang SL, Miao JY. Integrin beta4 mAb inhibited apoptosis induced by deprivation of growth factors in vascular endothelial cells. Acta Pharmacol Sin. 2004; 25(6): 733-7.
4.    Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ.Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. J Biol Chem. 2005 Dec 30;280(52):42707-14.
5.    Li X, Xu YB, Wang Q, Lu Y, Zheng Y, Wang YC, Lubbert M, Zhao KW, Chen GQ. Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells. J Cell Physiol. 2006; 208(3): 594-601.
6.    Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene. 2006; 25(50): 6618-27.
7.    Gao FH, Wang Q, Wu YL, Li X, Zhao KW, Chen GQ. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochem Biophys Res Commun. 2007; 356(2): 505-11.
8.    Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ. Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica. 2008 Oct;93(10):1480-7
9.    Guo P, Dong XY, Zhang X, Zhao KW, Sun X, Li Q, Dong JT. Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification. J Biol Chem. 2009 Mar 6;284(10):6071-8
10.    Guo P, Zhao KW, Dong XY, Sun X, Dong JT. Acetylation of KLF5 alters the assembly of P15 transcription factors in TGFbeta-mediated induction in epithelial cells. J Biol Chem. 2009 May 6. [Epub ahead of print].
11.    Guo P, Dong XY, Zhao KW, Sun X, Li Q, Dong JT. Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of TGFβ. J Biol Chem. in publication..