课题组长
吴英理
研究方向:化学生物学
办公地址:重庆南路280号新教学楼1005室
办公电话:86-021-63846590*776923
邮箱地址:wuyingli@shsmu.edu.cn
个人简介
吴英理,男,博士,副研究员。
2000年和2003年分别在第三军医大学和上海第二医科大学获得血液学硕士和博士学位。2004年—2006年在法国巴黎圣路易医院从事博士后研究。现在上海交通大学医学院病理生理学教研室工作,主要从事白血病发病学和治疗学方面的化学生物学研究。近年来在国际学术期刊如《Blood》,《Journal of Cell Science》等上发表了多篇论文。
最近几年来,主持两项国家自然科学基金面上项目和两项上海市科委重点基础项目。并于2005年获得上海市青年科技启明星计划资助,2008年获上海市医学科技奖一等奖(第二完成人),上海市自然科学奖一等奖(第二完成人)。
部分已发表文章
1. Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I, Aradi J, Lanotte M, Tong JH, Chen GQ, Segal-Bendirdjian E. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J Cell Sci. 2006, 119:2797-806.
2. Yin T#, Wu YL#, Sun HP, Sun GL, Du YZ, Wang KK, Zhang J, Chen GQ, Chen SJ, Chen Z. Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood, 2004, 104:4219-25. (#equally contributed to this work).
3. Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood, 2006, 107:698-707.
4. Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica, 2005, 90:1607-16.
5. Gao FH, Wang Q, Wu YL, Li X, Zhao KW, Chen GQ. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochem Biophys Res Commun. 2007, 356:505-11.
6. Yan H, Wang YC, Li D, Wang Y, Liu W, Wu YL, Chen GQ. Arsenic Trioxide and Proteasome Inhibitor Bortezomib Synergistically Induce Apoptosis in Leukemia Cells: the Role of Protein Kinase Cd. Leukemia, 2007, 21:1488-95.
7. Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ. Hypoxia-inducible factor-1a Induces Differentiation of Myeloid Leukemic Cells Through its Transcriptional Activity-Independent Mechanism. Oncogene. 2008, 27:519-27.
8. Yang L, Jiang Y, Wu SF, Zhou MY, Wu YL, Chen GQ. CAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction.Carcinogenesis. 2008;29:291-8.