详细信息
学术骨干
郑莹
办公地址:重庆南路280号新教学楼1003室
邮箱地址:zhengyingsh@126.com
个人简介
郑莹,博士,助理研究员。本科毕业于西北大学生物系生物化学专业。2004年~2009年,师承上海交通大学医学院陈国强教授,攻读病理学与病理生理学专业硕博连读研究生(五年制),并取得博士学位。毕业后,就职于上海交通大学医学院病理生理学教研室暨教育部细胞分化与凋亡重点实验室。在攻读博士学位期间,一直从事功能蛋白质组学研究,主要研究方向为NDRG1蛋白在白血病细胞凋亡中的作用和机制,该课题获得医学院博士创新基金的资助。通过努力工作,近五年来,以第一作者和参与作者在国际学术期刊上发表了10篇论著。
部分已发表文章
1.Zheng Y, Wang LS, Xia L, Han YH, Liao SH, Wang XL, Cheng JK, and Chen GQ. (2009) NDRG1 is downregulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKCd and apoptosis. Proteomics 9, 2064–2075.
2.Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q and Li D. (2008) NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells. Leukemia Res. 33, 1108-13.
3.Wang S, Zheng Y, Yu Y, Xia L, Chen GQ, Yang YZ, and Wang LS. (2008) Phosphorylation of beta-actin by protein kinase C-delta in camptothecin analog-induced leukemic cell apoptosis. Acta pharmacologica Sinica 29, 135-142.
4.Jin X, Wang LS, Xia L, Zheng Y, Meng C, Yu Y, Chen GQ, and Fang NY. (2008) Hyper-phosphorylation of alpha-enolase in hypertrophied left ventricle of spontaneously hypertensive rat. Biochemical and biophysical research communications 371, 804-809.
5.Jin X, Xia L, Wang LS, Shi JZ, Zheng Y, Chen WL, Zhang L, Liu ZG, Chen GQ, and Fang NY. (2006) Differential protein expression in hypertrophic heart with and without hypertension in spontaneously hypertensive rats. Proteomics 6, 1948-1956.
6.Han YH, Xia L, Song LP, Zheng Y, Chen WL, Zhang L, Huang Y, Chen GQ, and Wang LS. (2006) Comparative proteomic analysis of hypoxia-treated and untreated human leukemic U937 cells. Proteomics 6, 3262-3274.
7.Li X, Xu YB, Wang Q, Lu Y, Zheng Y, Wang YC, Lubbert M, Zhao KW, and Chen GQ. (2006) Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells. Journal of cellular physiology 208, 594-601.
8.Zhang L, Wang LS, Xu Y, Xia L, Chen WL, Zheng Y, and Chen GQ (2006) Comparative proteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein. The Chinese journal of physiology 49, 182-191.
9.Li ZF, Liu Q, Song MG, Zheng Y, Nan P, Cao Y, Chen GQ, Li YX, and Zhong Y. (2005) Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes. Bio Systems 82, 226-234.
10.Zhang N, Zhang HW, Xia L, Zheng Y, Yu Y, Zhu YS, Chen GQ, Di W (2009) NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1a protein in human ovarian cancer cells. Cancer Letters 278, 139-44.