详细信息
学术骨干
黄莺
办公地址:重庆南路225号健康科学研究所
办公电话:86-021-63846590*776856
邮箱地址:huangyingk@hotmail.com
个人简介
      黄莺,女,1994年在上海第二医科大学(现上海交通大学医学院)获得临床医学学士学位;2000年—2003年在二医大攻读生物化学和分子生物学硕士学位,主要从事低氧和低氧模拟物诱导白血病细胞分化机制的研究;2004年—2007年在交大医学院继续攻读病理生理学博士学位,期间,被派往美国休斯顿贝勒医学院开展合作研究两年,主要从事蛋白分子的核动力学研究。于研究生学习阶段,在国际刊物上作为第一作者和参与作者分别发表3篇和8篇论文,至目前为止,一共发表15篇论文。现在,在交大医学院病理生理学工作。
部分已发表文章
1. Yuan TT, Huang Y, Zhou CX, Yu Y, Wang LS, Zhuang HY, Chen GQ. Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis. Apoptosis. 2009;14(5):699-710.
2. Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ. Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica. 2008;93(10):1480-7.
3. Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 Isoforms ? and ?, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3 mapping to its unique C-terminal end. J Biol Chem. 2007;282(48):34958-34967.
4. Huang Y, Qiu J, Chen GQ, Dong S. Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARalpha, resulting in sequestration and decreased mobility of SMRT. Biochem Biophys Res Commun. 2008;365(2):258-265.
5. Qiu J, Huang Y, Chen GQ, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell. 2007;18(10):3941-3951.
6. Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S, Chen GQ. Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha. Oncogene.  2008;27(6):839-847
7. Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ. Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cellsis its transcriptional activity independent. Oncogene. 2008;27(4):519-527
8. Han YH, Xia L, Song LP, Zheng Y, Chen WL, Zhang L, Huang Y, Chen GQ, Wang LS. Comparative proteomic analysis of hypoxia-treated and untreated human leukemicU937 cells. Proteomics. 2006 Jun;6(11):3262-3274.
9. Chen GQ, Peng ZG, Liu W, Song LP, Jiang Y, Huang Y, Zhao Q. Hypoxia inducible
factor-1alpha and leukemic cell differentiation. Sheng Li Xue Bao. 2006;58(1):5-13.
10. Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica. 2005;90(12):1607-1616.
11. Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lübbert M, Chen GQ. Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha. Leukemia. 2005; 19(7):1239-1247.
12. Huang Y, Du KM, Xue ZH, Yan H, Li D, Liu W, Chen Z, Zhao Q, Tong JH, Zhu YS, Chen GQ. Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha. Leukemia. 2003; 17(11):2065-2073.
13. Cai X, Yu Y, Huang Y, Zhang L, Jia PM, Zhao Q, Chen Z, Tong JH, Dai W, Chen GQ. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. Leukemia. 2003; 17(7):1333-1337.
14. Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L, Huang Y, Zhang JW, Xiong SM, Chen SJ, Wang ZY, Chen Z, Chen GQ. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 2000; 14(2):262-270.
15. Zhu XH, Shen YL, Jing YK, Cai X, Jia PM, Huang Y, Tang W, Shi GY, Sun YP, Dai J, Wang ZY, Chen SJ, Zhang TD, Waxman S, Chen Z, Chen GQ. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J Natl Cancer Inst. 1999; 91(9):772-778.