学术骨干
夏立
办公地址:重庆南路280号新教学楼1007室
邮箱地址:lixia@shsmu.edu.cn
个人简介
夏立,男,1999年7月从原上海第二医科大学(医学本科)毕业后, 在本校工作至今,期间,曾在法国从事法语教学学习1个月余,于2005年晋升为讲师,并于2006年获得硕士学位,2007年始攻读博士学位。在教学工作中,在较短的时间内,即完成了整套病理生理学教学的大纲编写、备课,并积极配合教学主任很好的完成教学干事的任务,参与教学改革,在设计性试验的教材编写、论文撰写、课程编写中发挥了重要的作用。自2002年起,师从陈国强教授,作为在职硕士研究生参与到蛋白质组学技术平台的建设中,在一年时间内建立了以质谱为中心的一整套蛋白质组学平台,并与传统分子生物学结合,很好地应用于相关课题的研究中,包括低氧诱导的白血病分化治疗研究、喜树碱诱导白血病细胞凋亡的研究等,取得重要进展,2006年至今,在国际重要期刊接受发表10余篇论文,并以项目负责人获得国家自然基金青年项目资助。2007年度获校优秀青年教师,卢湾区青年岗位能手,2008年度获校青年教师提升计划。目前,继续在本实验室攻读博士学位,主要涉及蛋白-蛋白相互作用,蛋白质翻译后修饰等以蛋白质组学技术为核心的研究工作。
部分已发表文章
1.Han YH, Xia L, Song LP, Zheng Y, Chen WL, Zhang L, Huang Y, Chen GQ, Wang LS.Comparative proteomic analysis of hypoxia-treated and untreated human leukemic U937 cells. Proteomics. 2006 Jun;6(11):3262-74.
2.Jin X, Xia L, Wang LS, Shi JZ, Zheng Y, Chen WL, Zhang L, Liu ZG, Chen GQ, Fang NY. Differential protein expression in hypertrophic heart with and without hypertension in spontaneously hypertensive rats. Proteomics. 2006 Mar;6(6):1948-56. Erratum in: Proteomics. 2006 Apr;6(7):2326.
3.Zhang L, Wang LS, Xu Y, Xia L, Chen WL, Zheng Y, Chen GQ. Comparativeproteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein. Chin J Physiol. 2006 Aug 31;49(4):182-91.
4.Lu Y, Peng ZG, Yuan TT, Yin QQ, Xia L, Chen GQ. Multi-sites cleavage ofleukemogenic AML1-ETO fusion protein by caspase-3 and its contribution toincreased apoptotic sensitivity. Leukemia. 2008 Feb;22(2):378-86. Epub 2007 Nov8.
5.Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ. Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells.J Proteome Res. 2007 Sep;6(9):3808-18. Epub 2007 Jul 27.
6.Guo W, Qu F, Xia L, Guo Q, Ying X, Ding Z. Identification and characterizationof ERp29 in rat spermatozoa during epididymal transit. Reproduction. 2007Mar;133(3):575-84.
7.Jin X, Wang LS, Xia L, Zheng Y, Meng C, Yu Y, Chen GQ, Fang NY.Hyper-phosphorylation of alpha-enolase in hypertrophied left ventricle ofspontaneously hypertensive rat. Biochem Biophys Res Commun. 2008 Jul11;371(4):804-9. Epub 2008 May 9.
8.Zhang N, Zhang H, Xia L, Zheng Y, Yu Y, Zhu Y, Chen G, Di W. NSC606985 inducesapoptosis, exerts synergistic effects with cisplatin, and inhibitshypoxia-stabilized HIF-1alpha protein in human ovarian cancer cells. Cancer Lett.2009 Jun 18;278(2):139-44. Epub 2009 Mar 31.
9.Zheng Y, Wang LS, Xia L, Han YH, Liao SH, Wang XL, Cheng JK, Chen GQ. NDRG1 isdown-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis. Proteomics. 2009 Apr;9(8):2064-75.
10.Meng C, Jin X, Xia L, Shen SM, Wang XL, Cai J, Chen GQ, Wang LS, Fang NY.Alterations of mitochondrial enzymes contribute to cardiac hypertrophy beforehypertension development in spontaneously hypertensive rats. J Proteome Res. 2009May;8(5):2463-75.
11.Wang S, Zhang Z, Zhao J, Zhang X, Sun X, Xia L, Chang Q, Ye D, Jiang X.Vertical alveolar ridge augmentation with beta-tricalcium phosphate andautologous osteoblasts in canine mandible. Biomaterials. 2009 May;30(13):2489-98.Epub 2009 Jan 14.