详细信息
学术骨干
蒋益
办公地址:重庆南路280号新教学楼907室
办公电话:86-021-63846590*776403
邮箱地址:yijiang0215@gmail.com
个人简介

蒋益,女,上海交通大学医学院,教育部细胞分化与凋亡重点实验室,病理生理学教研室副教授,现任病理生理教研室党支部书记。

2005年获生物化学与分子生物学专业硕士学位。期间,致力于低氧模拟化合物——去铁胺(DFO)诱导髓系白血病(AML)细胞分化及其机制的研究。相关工作已经作为第一作者在《LEUKEMIA》杂志发表,并作为并列第一作者或第3作者在《APOPTOSIS》、《Hematologica》和《Biochem Biophys Res Commun》等发表论文。2004-2006年赴德国弗莱堡医学院从事白血病分化与凋亡机制的合作研究。2006年获国家自然科学基金资助一项HIF1a和C/EBPa蛋白相互作用和在白血病细胞分化中的作用。

部分已发表文章
1. Chen GQ, Peng ZG, Liu W, Song LP, Jiang Y, Huang Y, Zhao Q. Hypoxia inducible factor-1alpha and leukemic cell differentiation. Sino Acta Physiol. 2006 Feb;58(1):5-13.
2. Guo M, Song LP, Jiang Y, Liu W, Yu Y, Chen GQ. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms. Apoptosis. 2006 Jan;11(1):67-77.
3. Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica. 2005 Dec;90(12):1607-16.
4. Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ, Zhao Q. Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1alpha protein. Biochem Biophys Res Commun. 2005 Jul;332(4):1140-5.
5. Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lubbert M, Chen GQ. Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha. Leukemia. 2005 Jul;19(7):1239-47.