1. Huang Y, Du KM, Xue ZH, Yan H, Li D, Liu W, Chen Z, Zhao Q, Tong JH, Zhu YS, Chen GQ. Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1a. Leukemia. 2003; 17(11): 2065-2073.

2. Cai X, Yu Y, Huang Y, Zhang L, Jia PM, Zhao Q, Chen Z, Tong JH, Dai W, Chen GQ. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. Leukemia. 2003; 17 (7): 1333-1337.

3. Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ. Protein kinase Cd mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation. Blood. 2004; 104(12): 3731-3738.

4. Yin T, Wu YL, Sun HP, Sun GL, Du YZ, Wang KK, Zhang J, Chen GQ, Chen SJ, Chen Z. Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood. 2004; 104(13): 4219-4225.

5. Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica. 2005; 90 (12): 1607-1616.

6. Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ. Interferon-a-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cd and JNK. J Biol Chem. 2005; 280 (52): 42707-42714.

7. Fu GH, Wang Y, Xi YH, Guo ZW, Liu XB, Bai SZ, Yang BF, Chen GQ. As2O3 enhances the anion transport activity of band 3 and the action is related with the C-terminal 16 residues of the protein. J Drug Target. 2005; 13 (4): 235-243.

8. Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lubbert M, Chen GQ. Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1a that augments transcriptional activity of CCAAT/enhancer-binding protein-a. Leukemia. 2005; 19 (7): 1239-1247.

9. Yu Y, Chen S, Wang LS, Chen WL, Guo WJ, Yan H, Zhang WH, Peng CH, Zhang SD, Li HW, Chen GQ. Prediction of pancreatic cancer by serum biomarkers using surface-enhanced laser desorption/ionization-based decision tree classification. Oncology. 2005; 68 (1): 79-86.

10. Fu GH, Wang Y, Xi YH, Shen WW, Pan XY, Shen WZ, Jiang XS, Chen GQ. Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1). Febs Lett. 2005; 579 (10): 2105-2110.

11. Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH, Wang Q, Chen Z, Zhu YS, Chen GQ. Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cd-dependent mechanisms. Blood. 2005; 105(9): 3714-3721.

12. Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ, Zhao Q. Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1a protein. Biochem Bioph Res Co. 2005; 332(4): 1140-1145.

13. Li Z, Liu Q, Song M, Zheng Y, Nan P, Cao Y, Chen GQ, Li Y, Zhong Y. Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes. Biosystems. 2005; 82 (3): 226-234.

14. Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. AML1-ETO and C-KIT mutation/overexpression in t (8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. P Natl Acad Sci USA. 2005; 102(4): 1104-1109.

15. Zhang L, Wang LS, Xu Y, Xia L, Chen WL, Zheng Y, Chen GQ. Comparative proteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein. Chinese J Physiol. 2006; 49 (4): 182-191.

16. Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene. 2006; 25 (50): 6618-6627.

17. Han YH, Xia L, Song LP, Zheng Y, Chen WL, Zhang L, Huang Y, Chen GQ, Wang LS. Comparative proteomic analysis of hypoxia-treated and untreated human leukemic U937 cells. Proteomics. 2006; 6 (11): 3262-74.

18. Lu Y, Xu YB, Yuan TT, Song MG, Lubbert M, Fliegauf M, Chen GQ. Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis. Leukemia. 2006; 20 (6): 987-993.

19. Guo M, Song LP, Jiang Y, Liu W, Yu Y, Chen GQ. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1a independent mechanisms. Apoptosis. 2006; 11(1): 67-77.

20. Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood. 2006; 107 (2): 698-707.

21. Jin X, Xia L, Wang LS, Shi JZ, Zheng Y, Chen WL, Zhang L, Liu ZG, Chen GQ, Fang NY. Differential protein expression in hypertrophic heart with and without hypertension in spontaneously hypertensive rats. Proteomics. 2006; 6 (6): 1948-1956.

22. Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I, Aradi J, Lanotte M, Tong JH, Chen GQ, Segal-Bendirdjian E. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J Cell Sci. 2006; 119(Pt 13):2797-2806.

23. Li X, Xu YB, Wang Q, Lu Y, Zheng Y, Wang YC, Lubbert M, Zhao KW, Chen GQ. Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells. J Cell Physiol. 2006; 208 (3): 594-601.

24. Xiao S, Li D, Zhu HQ, Song MG, Pan XR, Jia PM, Peng LL, Dou AX, Chen GQ, Chen SJ, Chen Z, Tong JH. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. P Natl Acad Sci USA. 2006; 103 (44):16448-16453.

25. Ren H, Cao Y, Zhao Q, Li J, Zhou C, Liao L, Jia M, Zhao Q, Cai H, Han ZC, Yang R, Chen GQ, Zhao RC. Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions. Biochem Bioph Res Co. 2006; 347 (1): 12-21.

26. Pan XY, Chen GQ, Cai L, Buscemi S, Fu GH. Anion exchanger 2 mediates the action of arsenic trioxide. Brit J Haematol. 2006; 134 (5): 491-499.

27. Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ. Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells. J Proteome Res. 2007; 6(9): 3808-3818.

28. Xu M, Li D, Lu Y, Chen GQ. Leukemogenic AML1-ETO fusion protein increases carcinogen-DNA adduct formation with upregulated expression of cytochrome P450-1A1 gene. Exp Hematol. 2007; 35(8): 1249-1255.

29. Yan H, Wang YC, Li D, Wang Y, Liu W, Wu YL, Chen GQ. Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cd. Leukemia. 2007; 21 (7): 1488-1495.

30. Liu W, Zhu YS, Guo M, Yu Y, Chen GQ. Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia. Leukemia Res. 2007; 31(11): 1565-1574.

31. Gao FH, Wang Q, Wu YL, Li X, Zhao KW, Chen GQ. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochem Bioph Res Co. 2007; 356 (2): 505-511.

32. Chen GQ, Wang LS, Wu YL, Yu Y. Leukemia, an effective model for chemical biology and target therapy. Acta Pharmacol Sin. 2007; 28 (9): 1316-1324.

33. Qiu J, Huang Y, Chen GQ, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor a fusion proteins assessed at the single-cell level. Mol Biol Cell. 2007; 18(10): 3941-3951.

34. Wang Y, Wu SF, Chen GQ, Fu GH. Effect of block deletions in the C-terminus on the functional expression of human anion exchanger 1 (AE1). Mol Membr Biol. 2007; 24 (1):65-73.

35. Huang Y, Qiu JH, Chen GQ, Dong S. Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARa, resulting in sequestration and decreased mobility of SMRT. Biochem Bioph Res Co. 2008; 365(2): 258–265.

36. Yang L, Jiang Y, Wu SF, Zhou MY, Wu YL and Chen GQ. CCAAT/enhancer-binding protein a antagonizes transcriptional activity of hypoxia-inducible factor 1 a with direct protein–protein interaction. Carcinogenesis. 2008; 29(2): 291–298.

37. Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ. Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene. 2008; 27(4): 519–527.

38. Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S Chen GQ. Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1a. Oncogene. 2008; 27(6): 839–847.

39. Lu Y, Peng ZG, Yuan TT, Yin QQ, Xia L, Chen GQ. Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity. Leukemia. 2008; 22(2): 378–386.

40. Jin X, Wang LS, Xia L, Zheng Y , Meng C, Yu Y, Chen GQ, Fang NY.  Hyper-phosphorylation of a-enolase in hypertrophied left ventricle of spontaneously hypertensive rat. Biochem Bioph Res Co. 2008; 371(4): 804–809.

41. Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ. Accumulation of hypoxia-inducible factor-1a protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica. 2008; 93(10): 1480-1487.

42. Wang S, Zheng Y, Yu Y, Xia L, Chen GQ, Yang YZ, Wang LS. Phosphorylation of b-actin by protein kinase C-delta in camptothecin analog-induced leukemic cell apoptosis. Acta Pharmacol Sin. 2008; 29 (1): 135–142.

43. Zheng Y, Wang LS, Xia L, Han YH, Liao SH, Wang XL, Cheng JK, Chen GQ. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: The potential role in proteolytic activation of PKCd and apoptosis. Proteomics. 2009; 9(8): 2064–2075.

44. Zhao M, Duan XF, Wen DH, Chen GQ. PU.1, a novel capase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells. Biochem Bioph Res Co. 2009; 382(2): 508–513.

45. Meng C, Jin X, Xia L, Shen SM, Wang XL, Cai J, Chen GQ, Wang LS, Fang NY. Alterations of mitochondrial enzymes contribute to cardiac hypertrophy before hypertension development in spontaneously hypertensive rats. J Proteome Res. 2009; 8 (5): 2463-2475.

46. Yuan TT, Huang Y, Zhou CX, Yu Y, Wang LS, Zhuang HY, Chen GQ. Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis. Apoptosis. 2009; 14(5): 699–710.

47. Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q, Chen GQ, Li D. NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells. Leukemia Res. 2009; 33(8): 1108–1113.

48. Zhang N, Zhang HW, Xia L, Zheng Y, Yu Y, Zhu YS, Chen GQ, Di W. NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1a protein in human ovarian cancer cells. Cancer Lett. 2009; 278(2): 139–144.

49. Zhao Y, Pu JX, Huang SX, Wu YL, Yang YB, Xiao WL, Han QB, Chen GQ, Sun HD. ent-kaurane diterpenoids from Isodon scoparius. J Nat Prod. 2009; 72(1): 125–129.

50. Chen LY, Pan WW, Chen M, Li JD, Liu W, Chen GQ, Huang S, Papadimos TJ, Pan ZK. Synergistic induction of inflammation by bacterial products lipopolysaccharide and fMLP: an important microbial pathogenic mechanism. J Immunol. 2009; 182(4): 2518 –2524.

51. Yu H, Meng Y, Wang LS, Jin X, Gao LF, Zhou L, Ji K, Li Y, Zhao LJ, Chen GQ, Zhao XJ Yang B. Differential protein expression in heart in UT-B null mice with cardiac conduction defects. Proteomics. 2009; 9(3): 504–511.

52. Tan C, Cai LQ, Wu W, Qiao Y, Julianne Imperato-McGinley, Chen GQ, Zhu YS. NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells. Cancer Chemoth Pharm. 2009; 63(2): 303-312.

53. Zhang YJ, Dai Q, Sun DF, Xiong H, Tian XQ, Gao FH, Xu MH, Chen GQ, Han ZG, Fang JY. mTOR signaling pathway is a target for the treatment of colorectal cancer. Ann Surg Oncol. 2009; 16(9):2617-2628.

54. Xiong H, Chen ZF, Liang QC, Du W, Chen HM, Su WY, Chen GQ, Han ZG, Fang JY. Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signaling. J Cell Mol Med. 2009 Jan 16. [Epub ahead of print]

55. Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ. Proteomics-based identification of two novel direct targets of hypoxia- inducible factor-1a and their potential roles in migration/invasion of cancer cells. Proteomics. 2009; 9(15):3901-3912.

56. Yue F, Wang LS, Xia L, Wang XL, Feng B, Lu AG, Chen GQ, Zheng MH. Modulated T-complex protein 1 zeta and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: evidence from proteomics and bioinformatics. Proteomics Clinical Application. 2009, in press.

57. Zhao M, Duan XF, Zhao XY, Zhang B, Lu Y, Liu W, Cheng JK, Chen GQ. Protein kinase Cd stimulates proteasome-dependent degradation of C/EBPα during apoptosis induction of leukemic cells. PlosONE .2009; 4(8): e6552.

58. Zhang J, Chen GQ. Hypoxia-HIF-1α -C/EBPα /Runx1 signaling in leukemic cell differentiation. Pathophysiology. 2009; 16, 297-303.

59. Gao FH, Wu YL, Zhao M, Liu CX, Wang LS, Chen GQ. Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res. 2009;315(19):3250-3258.

60. Duan XF, Wu YL, Xu HZ, Zhao M, Zhuang HY, Wang XD, Yan H, Chen GQ. Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes. Chem Biol Interact. 2010;183 : 222-230.

61. Shen SM, Yu Y, Wu YL, Cheng JK, Wang LS, Chen GQ. Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells. Carcinogenesis. 2010;31(3):419-426.

62. Wu SF, Huang Y, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ.The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation. Leukemia. 2010; 24(3):544-551.

63. Xu HZ, Huang Y, Wu YL, Zhao Y, Xiao WL, Lin QS, Sun HD, Dai W, Chen GQ. Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function. Cell Cycle. 2010; 9(14): 1-11.